344 Foxo4 and AHR control inflammation-induced tissue damage via secretion of IL-22 in T cells

Epithelial barrier integrity is of outermost importance to protect the human body from external harm. One key cytokines involved in tissue regeneration interleukin (IL)-22. During inflammation, IL-22 producing cells are recruited into organs restore inflammation mediated damage. The aryl hydrocarbon receptor (AhR) has been shown regulate expression T cells. Previous results our group indicated that another transcription factor Forkhead box O (FOXO) 4 expressed FOXO4 mainly described as tumor suppressor and regulator senescence longevity. In line with this, mRNA various tissues at low level downregulated most tumors. protein have detected mouse CD4+ could assign Th22 subset. To investigate functional role cells, lentiviral overexpression, downregulation effector well naïve subsequently cultured under polarizing conditions, was performed. We show AhR IL22 secretion IL-6 TNF-α induced cell cultures while AhR-Agonist independent. A physiological dependent effects confirmed by scratch assays revealing decreased artificial wound healing supernatants deficient Here, we stabilized during vitro differentiation Furthermore, describe an important mediator for differentiating a pro-inflammatory setting.